Elevated natural killer cell levels and autoimmunity synergistically decrease uterine blood flow during early pregnancy

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Elevated natural killer cell levels and autoimmunity synergistically decrease uterine blood flow during early pregnancy

OBJECTIVE To investigate whether natural killer (NK) cell and autoimmune antibody acts synergistically, by the action of autoantibodies to increase NK cell number and cytotoxicity, to decrease uterine blood flow during early pregnancy in pregnant women with a history of recurrent spontaneous abortion (RSA). METHODS Seventy-five pregnant women (between 5 and 7 weeks gestation) with a history o...

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The regulation of ovary and conceptus on the uterine natural killer cells during early pregnancy

Uterine natural killer (uNK) cells are short-lived, terminally differentiated and the most abundant lymphocytes in the uterus which play a crucial role in the spiral arteriole modification and establishment of successful pregnancy. Dysregulation of uNK cells has been linked to gestational implications such as recurrent pregnancy loss, preeclampsia and fetal growth retardation. There is evidence...

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Expression of angiogenic growth factors by uterine natural killer cells during early pregnancy.

Remodeling of uterine spiral arteries is critical for the continuation of a successful pregnancy. Uterine natural killer (uNK) cells are the predominant leukocyte population in the early pregnant decidua, and a role for these cells in spiral artery remodeling in pregnancy has been suggested. Angiogenic growth factors were measured in isolated uNK and total (unseparated) decidual cells (8-10 or ...

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Uterine natural killer cell partnerships in early mouse decidua basalis.

The decidua basalis of developing mouse implantation sites is highly enriched in CD45+ leukocytes. In intact, syngeneically mated C57BL/6 decidua basalis examined at gestation day 8.5 by whole-mount in situ immunohistochemistry, leukocyte, but not trophoblast, conjugations were reported. Nothing is known regarding time course, frequency, composition, or importance of physiologic decidual CD45+ ...

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Uterine Blood Flow Indices in Sheep during Pregnancy

To understand the different changes and events that occur in humans from conception until labour our experimental animal model is the ewe. Some studies use laboratory rodents, non-human primates and domestic ruminants as a model for research relevant to human pregnancies.1 Sheep, humans and other higher primates have villous interdigitation, wherein the chorion has a tree-like branching pattern...

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ژورنال

عنوان ژورنال: Obstetrics & Gynecology Science

سال: 2014

ISSN: 2287-8572,2287-8580

DOI: 10.5468/ogs.2014.57.3.208